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Hyaluronic Acid Research Sources
July 23rd, 2010 -

Hyaluronic acid is one of the most researched substances in medicine today and is backed by thousands of clinical trials in the fields of orthopedics and eye surgery. If you’d like to learn more about the benefits of hyaluronic acid, the following resources will provide you with a starting point for further research.

  1. Marshall KW. Viscosupplementation of HA: current status, unresolved issues and future directions. J Rheumatol 1998;25:2056-8.
  2. George E. Intra-articular hyaluronan. Ann Rheum Dis 1998;57:637-40.
  3. Wobig M, Bach G, Beks P, Dickhut A, Runzheimer J, Schwieger G, et al. The role of elastoviscosity in the efficacy of viscosupplementation for the knee: a comparison of hylan G-F 20 and a lower-molecular-weight hyaluronan. Clin Ther 1999;21:1549-62.
  4. Cohen MD. Hyaluronic acid treatment (viscosupplementation) for OA of the knee. Bull Rheum Dis 1998;47:4-7.
  5. Balazs EA, Denlinger JL. Viscosupplementation: a new concept in the treatment for the knee. J Rheumatol 1993;20(suppl 39):3-9.
  6. Weiss C, Balazs EA, St. Onge R, Denlinger JL. Clinical studies of the intraarticular injection of HealonR (sodium hyaluronate) in the treatment of human knees. symposium. Palm Aire, Fla., October 20-22, 1980. Semin Arthritis Rheum. 1981;11(suppl 1):143-4.
  7. Peyron JG. Intraarticular hyaluronan injections in the treatment of the knee: state-of-the-art review. J Rheumatol 1993;39(suppl):10-5.
  8. Henderson EB, Smith EC, Pegley F, Blake DR. Intra-articular injections of 750 kD hyaluronan in the treatment of the knee: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy. Ann Rheum Dis 1994;53:529-34.
  9. Lohmander LS, Dalen N, Englund G, Hamalainen M, Jensen EM, Karlsson K, et al. Intra-articular hyaluronan injections in the treatment of the knee: a randomised, double blind, placebo controlled multicentre trial. Hyaluronan Mulicentre Trial Group. Ann Rheum Dis 1996;55:424-31.
  10. Dougados M, Nguyen M, Listrat V, Amor B. High molecular weight sodium hyaluronate (hyalectin) for the knee: a 1 year placebo-controlled trial. Cart 1993;1:97-103.
  11. Marshall KW. Viscosupplementation: current status, unresolved issues and future directions. J Rheumatol 1998;25:2056-8.
  12. Listrat V, Ayral X, Paternello F, Bonvarlet JP, Simonnet J, Amor B, et al. Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in the knee. Cart 1997;5:153-60.
  13. Altman RD, Moskowitz R. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patient’s knee: a randomized clinical trial. J Rheumatol 1998;25:2203-12 [Published erratum appears in J Rheumatol 1999;26:1216].
  14. Wobig M, Dickhut A, Maier R, Vetter G. Viscosupplementation with hylan G-F 20: a 26-week controlled trial of efficacy and safety in the knee. Clin Ther 1998;20:410-23.
  15. Adams ME, Atkinson MH, Lussier AJ, Schulz JI, Siminovitch KA, Wade JP, et al. The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone. Cart 1995;3:213-25.
  16. Lussier A, Cividino AA, McFarlane CA, Olszynski WP, Potashner WJ, De Medicis R. Viscosupplementation with hylan for the treatment of: findings from clinical practice in Canada. J Rheumatol 1996;23:1579-85.
  17. Disla E, Infante R, Fahmy A, Karten I, Cuppari GG. Recurrent acute calcium pyrophosphate dihydrate arthritis following intraarticular hyaluronate injection. Arthritis Rheum 1999;42:1302-3.
  18. Maheu E. Hyaluronan in knee: a review of the clinical trials with hyalgan. Eur J Rheumatol Inflamm 1995;15:17-24.

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